Open challenges in magnetic drug targeting

Open challenges in magnetic drug targeting - onlineLibraryTPS.asp

The principle of magnetic drug targeting, wherein therapy is attached to magnetically responsive carriers and magnetic fields are used to direct that therapy to disease locations, has been around for nearly two decades. Yet our ability to safely and effectively direct therapy to where it needs to go, for instance to deep tissue targets, remains limited. To date, magnetic targeting methods have ...

Magnetic Graphene Oxide Nanocarrier as a drug delivery vehicle for MRI monitored magnetic targeting of rat brain tumors

Introduction: Glioblastoma multiform is the most common malignant brain tumor, with an invasive nature. Despite the development of conventional therapies such as surgery, radiotherapy and chemotherapy, because of high recurrence rates, the prognosis remains very poor. Over the last decade, nanotechnology has represented an innovative method as nanoparticle-based drug delivery ...

Locoregional cancer treatment with magnetic drug targeting.

The specific delivery of chemotherapeutic agents to their desired targets with a minimum of systemic side effects is an important, ongoing challenge of chemotherapy. One approach, developed in the past to address this problem, is the i.v. injection of magnetic particles [ferrofluids (FFs)] bound to anticancer agents that are then concentrated in the desired area (e.g., the tumor) by an external...

Designated magnetic field design for magnetic drug guidance in BNCT

In this paper, a local magnetic field was designed and simulated using a Helmholtz coil along with a ferromagnetic core with an appropriate geometric Structure to concentrate a magnetic flux. This field can be used for magnetic guiding of Boron-borne drugs in BNCT.

Magnetic Particles in Biotechnology: From Drug Targeting to Tissue Engineering